Insulin-resistant diabetes mellitus Insulin-resistant diabetes mellitus at puberty Insulin-resistant diabetes mellitus at puberty A type of insulin-resistant diabetes mellitus that develops around the time of publerty in contrast to the common form of type 2 diabetes-associated insulin resistance that typically presents in mid-to-late adulthood. HP:0000877 Subjects affected by congenital generalized lipodystrophy (CGL) develop insulin resistance in early childhood and almost half of them manifest diabetes mellitus at puberty. In these patients diabetes mellitus is resistant to ketosis, meaning that there is a tendency not to develop ketoacidosis despite marked hyperglycemia.