Erythroderma SNOMEDCT_US:396349005 SNOMEDCT_US:200948000 HP:0001019 SNOMEDCT_US:399992009 SNOMEDCT_US:396350005 Generalised erythroderma Erythroderma can occur at any age. Erythroderma with a congenital or neonatal onset has a different differential diagnosis than adult-onset erythroderma. Several skin disorders may culminate with erythroderma: seborrheic dermatitis/sarcoidosis; contact (allergic or irritant) dermatitis (eg, stasis dermatitis with generalization); atopic dermatitis/autoimmune disease (systemic lupus/dermatomyositis/bullous pemphigoid/pemphigus foliaceus/lichen planus/graft-versus-host disease); lymphoma/leukemia (including Sézary syndrome); psoriasis, including Reiter syndrome/pityriasis rubra pilaris (PRP); infections (human immunodeficiency virus, dermatophytosis), ichthyoses, infestations (Norwegian scabies); drug reactions. Some cases are also associated with erosions (loss of epidermis with an epidermal base), crusting (serous, sanguineous, or pustular), and the potential for hair and nail changes. Exfoliative dermatitis and erythroderma (the preferred term) have been used synonymously in the literature. Generalized erythroderma Generalized erythrodermia An inflammatory exfoliative dermatosis involving nearly all of the surface of the skin. Erythroderma develops suddenly. A patchy erythema may generalize and spread to affect most of the skin. Scaling may appear in 2-6 days and be accompanied by hot, red, dry skin, malaise, and fever. Red scaly skin caused by inflammatory skin disease UMLS:C0011606 SNOMEDCT_US:400005007 Exfoliative dermititis Generalised erythrodermia Inflammatory abnormality of the skin