X-linked inheritance X-linked dominant inheritance An X-linked dominant condition would be curated as monoallelic_X_heterozygous and we would understand that those diseases will manifest in heterozygous females and hemizygous males. Disease or affected males may be rarely observed if hemizygosity of the variant allele is extremely severe or lethal. Similarly, homozygous/compound heterozygous females may be seen with more severe manifestations. X-linked dominant A mode of inheritance that is observed for dominant traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked dominant disorders tend to manifest very severely in affected males. The severity of manifestation in females may depend on the degree of skewed X inactivation. monoallelic_X_heterozygous UMLS:C1847879 HP:0001423