Typified by somatic mosaicism HP:0001444 Somatic mutation A much lower variant allele fraction (VAF) cutoff would be needed in genomic analysis pipelines as compared with the threshold required for constitutional variants. HP:0001442 UMLS:C1866227 Description of conditions in which affected individuals typically display somatic mosaicism, i.e., genetically distinct populations of somatic cells in a given organism caused by DNA mutations, epigenetic alterations of DNA, chromosomal abnormalities or the spontaneous reversion of inherited mutations. In many conditions typified by somatic mosaicism, constitutive mutation is lethal and cases are exclusively or predominantly mosaic. HP:0001428 Somatic mosaicism Autosomal dominant somatic cell mutation Inheritance qualifier