Stroke Ischemic stroke HP:0002140 UMLS:C0948008 Ischaemic stroke SNOMEDCT_US:422504002 Acute ischemic stroke (AIS) is defined by the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. It is caused by thrombosis or embolism that occludes a cerebral vessel supplying a specific area of the brain. During a vessel occlusion, there is a core area where damage to the brain is irreversible and an area of penumbra where the brain has lost function owing to decreased blood flow but is not irreversibly injured. Cerebral ischemia Cerebral infarct