Morphological central nervous system abnormality Alzheimer disease UMLS:C1863051 Late-onset form of familial Alzheimer disease Alzheimer disease Note that this is a bundled term that refers to a disease rather than to phenotypic features. It is retained for convenience since Alzheimer disease is used for annotation of other diseases (e.g., Down syndrome) as if it were a feature. If possible it is preferable to annotate with the precise phenotypic features. MONDO:0004975 HP:0007213 HP:0002511 SNOMEDCT_US:26929004 HP:0006878 SNOMEDCT_US:230267005 DOID:10652 A degenerative disease of the brain characterized by the insidious onset of dementia. Impairment of memory, judgment, attention span, and problem solving skills are followed by severe apraxia and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of senile plaques, neurofibrillary tangles, and neuropil threads. UMLS:C0002395