Lymphadenopathy Follicular hyperplasia UMLS:C4014733 HP:0002729 Lymphadenopathy (enlargement of lymph nodes) owing to hyperplasia of follicular (germinal) centers. Lymphadenopathy can be defined as enlargement of lymph nodes. It is just a sign accompanying a great variety of entities with multiple etiologies: acute vs. chronic, benign vs. malignant. One of the most commonly seen histological pictures is lymphadenopathy owing to hyperplasia of follicular (germinal centers) but this one is by far not the only one.