Increased proportion of HLA DR+ CD4+ T cells UMLS:C1858974 Increased proportion of HLA DR+ T cells Increased HLA DR+ T cell proportion HP:0002853 Increased HLA DR+ CD4+ T cell proportion Abnormal increase of the activated HLA-DR+ CD4+ T cell subpopulation, measured as percentage of total CD4+ T cells in the blood, compared to a reference range for a given sex and age-group. HLA-DR is an MHC class II cell surface receptor that presents antigens (peptides of at least 9 amino acids), thereby constituting a ligand for the T-cell receptor. HLA-DR can be upregulated in response to immune stimulation. Abnormal HLA DR+ CD4+ T cell proportion