Reduced glutathione synthetase level HP:0003343 SNOMEDCT_US:234589002 UMLS:C0398746 SNOMEDCT_US:39112005 SNOMEDCT_US:124706000 Glutathione synthetase deficiency Reduced level of the enzyme glutathione synthetase, which catalyzes the last step in the synthesis of glutathione and a deficiency results in low levels of glutathione. Acidosis is due to reduced feedback inhibition of gamma-glutamyl cysteine synthetase in the gamma-glutamyl cycle, which ultimately leads to overproduction and accumulation of 5-oxoproline. Abnormal circulating enzyme concentration or activity