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    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
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    <!-- http://purl.obolibrary.org/obo/HP_0000271 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0000271">
        <rdfs:label>Abnormality of the face</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/HP_0000929 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0000929">
        <rdfs:label>Abnormal skull morphology</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/HP_0004439 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0004439">
        <rdfs:label>Craniofacial dysostosis</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/HP_0000271"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/HP_0000929"/>
        <dcterms:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2008-03-18T09:58:00Z</dcterms:date>
        <oboInOwl:hasExactSynonym>Crouzon syndrome</oboInOwl:hasExactSynonym>
        <oboInOwl:id>HP:0004439</oboInOwl:id>
        <oboInOwl:hasDbXref>UMLS:C0010273</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>SNOMEDCT_US:28861008</oboInOwl:hasDbXref>
        <rdfs:comment>Note: This term is used in the medical literature to describe an appearance of the face of patients with Crouzon syndrome (also called craniofacial dysostosis), which is characterized by acrocephaly, exophthalmos, hypertelorism, strabismus, parrot-beaked nose, and hypoplastic maxilla. This is thus probably mainly used as a bundled term and should be replaced by better descriptions in the future.</rdfs:comment>
        <ns3:IAO_0000115>A characteristic appearance resulting from defective ossification of craniofacial bones.</ns3:IAO_0000115>
        <dcterms:creator rdf:resource="https://orcid.org/0000-0002-0736-9199"/>
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