Hypersegmentation of neutrophil nuclei Neutrophils usually display 3-4 nuclear lobes. Hypersegmented neutrophile nuclei display 5 or more lobes. This feature can be seen in vitamin B12 or folate deficiency or with other etiologies. UMLS:C4025288 An excessive division of the lobes of the nucleus of a neutrophil. Hypersegmentation of neutrophil nuclei in peripheral blood HP:0004821 Hypermature neutrophils Abnormal neutrophil morphology