Reduced kininogen activity Williams factor deficiency HP:0005527 SNOMEDCT_US:27312002 Kininogen is cleaved into the following 6 chains: 1) Kininogen-1 heavy chain; 2) T-kinin; 3) Bradykinin; 4) Lysyl-bradykinin; 5) Kininogen-1 light chain; and 6) Low molecular weight growth-promoting factor. Kininogen deficiency HP:0005530 HP:0005500 Amount or activity of kininogen is below the lower limit of normal. Kininogen functions as a cofactor in the contact phase of the intrinsic blood coagulation cascade. Williams-Fitzgerald-Flaujeac factor deficiency HP:0005538 UMLS:C0272340 Fitzgerald factor deficiency HP:0004867 Abnormal kinin-kallikrein system component activity Abnormality of the intrinsic pathway