Abnormal kinin-kallikrein system component activity 2008-03-27T10:34:00Z HP:0005559 UMLS:C4025178 The activity or concentration of a component of the kinin-kallikrein system is outside the limits of normal. The kinin-kallikrein system (KKS) is a peptide cascade involved in several physiological processes such as inflammation, coagulation, pain, blood pressure control, and vascular permeability. In the KKS, kinins originate from kininogens through the action of tissue and plasma kallikreins. Some impacts of kinins are induced via activation of B1 and/or B2 receptors and downstream signaling such as nitric oxide. Abnormal circulating protein concentration