Imbalanced hemoglobin synthesis 2008-03-27T10:44:00Z While imbalanced hemoglobin synthesis can be inferred from other findings including those of hemoglobin electrophoresis, the determination of this feature requires investigation of hemoglobin synthesis in vitro, e.g., by incubation of washed peripheral blood erythrocytes and bone marrow cells with radioactively labeled leucine followed by column chromatography. HP:0005560 Imbalanced haemoglobin synthesis Imbalanced Hb synthesis UMLS:C4025177 Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia. Abnormal hemoglobin