Reduced factor VII activity UMLS:C4024722 SNOMEDCT_US:37193007 HP:0008169 Factor VII deficiency Reduced activity of coagulation factor VII. Factor VII is part of the extrinsic coagulation pathway, which is initiated at the site of injury in response to the release of tissue factor (fIII). Tissue factor and activated factor VII catalyze the activation of factor X. UMLS:C0015503 Abnormality of the extrinsic pathway