Abnormality of pain sensation Trophic changes related to pain 2010-07-10T07:23:26Z HP:0010834 UMLS:C4021220 Trophic changes Trophic changes is a term used to describe abnormalities in the area of pain that include primarily wasting away of the skin, tissues, or muscle, thinning of the bones, and changes in how the hair or nails grow, including thickening or thinning of hair or brittle nails.