Congenital hypertrophy of retinal pigment epithelium Multiple congenital hypertrophy of retinal pigment epithelium 2012-04-06T09:25:33Z UMLS:C4021144 Multiple bilateral congenital hypertrophy of retinal pigment epithelium Unilateral or bilateral small, well-demarcated pigmented lesions localized in the retinal pigment epithelium (RPE). Lesions are dark in the center, with a pale circumference and are mostly located in the periphery. Multiple bilateral CHRPE HP:0011529 Bilateral multiple CHRPE is strongly associated with familial adenomatous polyposis coli.