Abnormality of humoral immunity Circulating immune complexes 2013-03-30T07:27:21Z HP:0012224 Persistence of immune complexes in the blood circulation. Immune complexes are formed of interlocking antigens and antibodies and are normally are rapidly removed from the bloodstream by macrophages in the spleen and Kupffer cells in the liver. If they persist abnormally in the circulation, they may become trapped in various tissues and induce inflammatory reactions. UMLS:C3887628