Aplasia of the vagina Aplasia of the upper vagina 2014-02-27T11:00:26Z HP:0012673 Absent upper vagina A failure to develop of the upper vagina. UMLS:C4022788 The female reproductive tract primarily develops from the Mullerian ducts (MD), which form as an invagination of the coelomic epithelium and further develop into the upper two-thirds of the vagina, the uterus and the Fallopian tubes. Complete aplasia of the uterus, cervix, and upper vagina is termed Mullerian aplasia. This term refers to the aplasia of the upper roughly two thirds of the vagina that is characteristic of Mullerian aplasia.