Retinal hamartoma Retinal astrocytic hamartoma 2014-04-07T05:38:54Z HP:0012778 A glial tumor of the retinal nerve fiber layer arising from a retinal astrocyte. UMLS:C4022725 Classically retinal astrocytic hamartomas appear as a cream-white, well-circumscribed, elevated lesions that may present as multiple or solitary sites. A lesion is commonly seen with a multilobulated, "mulberry" appearance, but can also appear flat and semitranslucent. It is most frequently associated with tuberous sclerosis but may also be found rarely in patients with neurofibromatosis. Although the finding may point toward a systemic association, it can also be found incidentally on retinal examination as an isolated presentation.