Anophthalmia Clinical anophthalmos 2025-07-30T14:37:29Z Congenital anophthalmos is a rare ocular anomaly in which histologically detectable eyeball structures are absent due to poor development of the primary optic nerve vesicle. However, with appropriate imaging or intraoperatively, rudimentary remains of this structure can usually be detected. Therefore, the term clinical congenital anophthalmos seems more appropriate and denotes a phenotypic range between microphthalmos and anophthalmos.