Irregularity of the retinal pigment epithelium layer on OCT 2025-10-26T10:37:00Z Lack of uniformity in the morphology of the retinal pigment epithelium (RPE) layer observed on optical coherence tomography (OCT) imaging. The RPE lies between the neurosensory retina (photoreceptors) and Bruch membrane/choroid, and normally appears as a thin, hyperreflective (bright) band on OCT imaging. This term comprises irregularities which may manifest as thickening, thinning, undulations, or loss of normal reflectivity, potentially affecting retinal structure or function. Abnormal optical coherence tomography