Abnormal lymph-node follicle architecture Colonization of follicles by lymphoma cells 2023-11-10T17:36:23Z Follicular colonisation Follicular colonization In contrast to follicular lymphoma, which typically is a lymphoma that forms follicles or potentially completely replaces normal follicles, some lymphomas (most commonly marginal zone lymphoma) can infiltrate normal follicles so both normal lymphocytes and the infiltrating lymphoma cells are present. This is called colonization of follicles by the lymphoma cells.