Abnormal lymph-node germinal center morphology Progressive transformation of germinal centers 2023-11-10T19:37:12Z PTGC While PTGC is a relatively common finding, there is an association with nodular lymphocyte predominant Hodgkin lymphoma, and morphologically may mimic follicular lymphoma (as well as immunohistochemically with regard to BCL2 staining if not carefully evaluated at high magnification), particularly the floral variant. This is a condition sometimes seen in a subset of germinal centers of reactive lymph nodes where germinal centers become enlarged and infiltrated by benign mantle zone cells and some T cells.