Neoplasm of head and neck Head and neck squamous cell carcinoma 2026-08-07T11:04:09Z Head and neck squamous cell carcinomas develop from the mucosal epithelium in the oral cavity, pharynx and larynx and are the most common malignancies that arise in the head and neck A squamous cell carcinoma that arises arising from the squamous mucosal epithelium of the upper aerodigestive tract (the oral cavity, pharynx (naso-, oro-, and hypopharynx), and larynx.