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    <!-- http://purl.obolibrary.org/obo/HP_0011121 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0011121">
        <rdfs:label>Abnormal skin morphology</rdfs:label>
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    <!-- http://purl.obolibrary.org/obo/HP_0025082 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/HP_0025082">
        <rdfs:label>Abnormal cutaneous elastic fiber morphology</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/HP_0011121"/>
        <dcterms:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2016-10-15T12:16:20Z</dcterms:date>
        <ns3:IAO_0000115>Any structural anomaly of the elastic fibers of the skin. Elastic fibers are the essential extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils.</ns3:IAO_0000115>
        <oboInOwl:hasExactSynonym>Abnormal cutaneous elastic fibre morphology</oboInOwl:hasExactSynonym>
        <rdfs:comment>Elastic fibers help the skin return to its normal configuration after being stretched or deformed. The elastic fibers consist of two components: microfibrils and matrix elastin. The microfibrillar component amounts to only 15% of the elastic fiber, whereas the amorphous, electron-lucid elastin makes up 85% of the fiber. In light microscope sections that are routinely stained, elastic fibers are inconspicuous. With special elastic tissue stains, such as orcein or resorcin-fuchisin, or in plastic-embedded sections they are found entwined among the collagen bundles [PMID:21738362].</rdfs:comment>
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