Aggravated by Exacerbated by head trauma 2016-12-21T02:22:58Z Applies to a sign or symptom that is worsened, aggravated, or exacerbated by head trauma. Childhood ataxia with central nervous system hypomyelination/vanishing white matter disease is an autosomal recessive disorder characterized by ataxia, spasticity, and variable optic atrophy. Chronic progressive decline can be exacerbated by rapid deterioration during febrile illnesses or following head trauma.