Abnormal nervous system physiology Perisylvian FDG hypermetabolism 2022-01-31T04:50:28Z 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (FDG-PET/CT) evaluates the glucose metabolism of the brain. FDG uptake is interpreted to represent glycolysis. This term therefore represents an abnormally increased FDG uptake (increased glucose metabolism) in the region of the brain that surrounds the Sylvian fissure. Perisylvian hypermetabolism in FDG PET