Decreased PMA/ionomycin-induced T-cell proliferation 2025-04-27T06:35:39Z Abnormal decrease of T cell proliferation in response to phorbol-12-myristate-13-acetate (PMA) and ionomycin stimulation. This is commonly measured through intracellular expression of Ki67, decreasing surface expression of carboxyfluorescein diacetate (CFSE), or 3H-thymidine incorporation. Length of incubation and strength of stimulation may vary between laboratories. Decreased proliferation in response to PMA/ionomycin Decreased mitogen-induced T-cell proliferation