Reduced erythrocyte 2,3-diphosphoglycerate concentration UMLS:C4022546 This term refers to an inappropriate low 2,3-DPG concentration in erythrocytes. 2,3-diphosphoglycerate (2,3-DPG) controls the movement of oxygen from red blood cells to tissues. Anemia is usually accompanied by an increased level of 2,3-DPG in order to promote tissue oxygenation. Abnormal erythrocyte metabolite concentration