Abnormal retinal vascular morphology Retinal neovascularization 2015-12-21T23:35:47Z HP:0007850 In ischemic retinal disease, neovascularization (NV) involves the sprouting of new vessels from pre-existent vessels. Ischemia invariably leads to the upregulation of Vascular Endothelial Growth Factor (VEGF) production. Most frequently the new vessels grow internal to the plane of the retina. However, intraretinal proliferation of new vessels can also occur. Retinal vascular proliferation SNOMEDCT_US:61267008 UMLS:C0035320