Autoimmune antibody positivity Liver kidney microsome type 1 antibody positivity 2016-07-19T08:09:20Z Anti-LKM1 antibody positivity Anti-type I liver-kidney microsomal antibody positivity The presence of autoantibodies (immunoglobulins) in the serum that react against P450 2D6, a cytochrome P450 mono-oxygenase. Anti-LKM-1 antibodies are considered to be a diagnostic marker of autoimmune hepatitis type 2 (AIH2). Anti-LKM-1 positive HP:0034113 Anti-liver kidney microsomal type 1 antibody positivity LKM1 is conventionally detected by immunofluorescence (IFL), a subjective technique, using rat liver, kidney, and stomach as a composite substrate.