Abnormality of pulmonary circulation Pulmonary venous hypertension 2017-01-13T21:56:41Z Common causes of pulmonary venous hypertension are obstruction to left ventricular (LV) inflow, LV systolic dysfunction, severe mitral regurgitation, and acute pulmonary and systemic volume overload. As the pulmonary venous pressure nears 22 mm Hg, interstitial pulmonmary edema may develop. As it reaches 25 mm Hg, alveolar edema may ensue. An abnormal increase in pressure in the pulmonary veins, usually as a result of left atrial hypertension.