Abnormal response to endocrine stimulation test Abnormal response to gonadotropin-releasing hormone stimulation test 2017-08-13T16:47:03Z Abnormal response to GnRH stimulation test This test is regarded as the gold standard to identify central precocious puberty. An abnormal response to the gonadotropin-releasing hormone (GnRH) stimulation test. This test typically involves intravenous administration of GnRH followed by repeated blood sampling at various time points to measure the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).