Abnormal cardiomyocyte morphology Myocardial sarcomeric disarray 2017-08-27T13:11:25Z Myocardial sarcomere disarray A disruption of the structure of the sarcomeres of cardiomyocytes. The sarcomere is the repeating unit between two Z lines comprised largely of myosin and actin that mediates contractility, and normally sarcomeres are aligned with the long axis of cells, with the Z bands being in register throughout the length of the cardiac myocytes. Cardiac biopsy: myocyte disarray Cardiomyocyte disarray