Decreased mitogen-induced T-cell proliferation Decreased anti-CD3/28-induced T-cell proliferation 2017-09-02T15:57:46Z Defective lymphocyte proliferation to anti-CD3 CD3 is the T-cell co-receptor. Abnormal decrease of T cell proliferation in response to anti-CD3/28 stimulation. This is commonly measured through intracellular expression of Ki67, decreasing surface expression of carboxyfluorescein diacetate (CFSE), or 3H-thymidine incorporation. Length of incubation and strength of stimulation may vary between laboratories. Defective proliferation of lymphocytes following anti-CD3 stimulation Decreased lymphocyte proliferation in response to anti-CD3