Abnormal esophagus physiology Ineffective esophageal peristalsis 2018-05-05T18:42:33Z Ineffective esophageal motility Reduced or inadequate esophageal peristalsis, with resultant slow passage of contents through the esophagus. Ineffective esophageal motility can be diagnosed by high-resolution manometry if 50% or more swallows are ineffective (failed or weak with the distal contractile integral less than 450 mmHg/s/cm). Hypoperistalsis