Semidominant inheritance 2018-11-17T14:33:51Z Semidominant mode of inheritance Familial hypercholesterolemia is an example of a disease with this inheritance pattern. A mode of inheritance that is observed for traits related to a gene encoded on chromosomes in which a trait can manifest in a monoallelic (e.g. heterozygotes) and biallelic (e.g. homozygotes, compound heterozygotes) state, with similar or differing phenotype severity present dependent on the number of alleles affected. Mendelian inheritance