Unusual Histoplasma capsulatum infection Severe Histoplasma capsulatum infection 2019-01-27T18:15:01Z Disseminated histoplasmosis Progressive disseminated histoplasmosis Severe histoplasmosis Histoplasmosis infection involving multiple sites of the body. Disseminated histoplasmosis can involve various organs, including reticuloendothelial organs, gastrointestinal tract, adrenal glands, central nervous system, endovascular structures, kidney, and skin. It typically presents with systemic symptoms like fever, generalized fatigue, night sweats, weight loss, and the symptoms related to the specific organ involved. Severe disseminated disease can manifest as septic shock, multi organ failure, and ARDS. Invasive histoplasmosis