Severe dermatophyte infection Disseminated dermatophytosis 2019-05-26T10:37:28Z Disseminated dermatophytosis tends to occur in patients with both defi cient T cell-mediated immunity and an impaired infl ammatory response. This process occurs either by direct extension, draining lymphatics, or hematogenous spread. It can present with involvement of distant skin areas, lymph nodes, bone, muscle, liver, spleen, testes or the central nervous system. Ultimately, disseminated infection can result in bacterial superinfection, osteomyelitis, organ dysfunction and eventual death. A type of invasive dermatophyte infection characterized by vascular involvement and dissemination to other organs.