Abnormality of temperature regulation Inappropriate absence of fever 2020-08-29T13:06:30Z Failure to develop fever in the presence of an infection that normally would be expected to elicit a febrile response. The induction and maintenance of fever during infection involves the tightly coordinated interplay between the innate immune system and neuronal circuitry within the central and peripheral nervous systems. Some diseases (such as Hyper-IgE recurrent infection syndrome 5, autosomal recessive, which is due to IL6R mutation) are associated with a lack of clinically adequate inflammatory response in the face of marked infection.