Hyperimidodipeptiduria 2020-10-04T11:55:48Z Prolidase splits dipeptides containing C-terminal proline or hydroxyproline. In prolidase deficiency, normal recycling of proline cannot occur, and this leads to iminopeptiduria, the characteristic biochemical abnormality. Glycylproline is the major urinary imidodipeptide. Leucylproline can also be identified in persons with prolidase deficiency. Imidodipeptiduria Elevated levels of proline-containing dipeptides in urine. Abnormal urine metabolite level