Increased circulating interleukin 10 concentration 2020-10-11T12:18:51Z IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages, all of which are required for optimal pathogen clearance but also contribute to tissue damage. In consequence, IL-10 can both impede pathogen clearance and ameliorate immunopathology. Increased serum interleukin 10 An elevation of the concentration of interleukin 10 in the blood circulation. Abnormal circulating interleukin 10 concentration