Abnormal pulmonary interstitial morphology Pulmonary necrosis 2020-11-24T11:51:10Z Cellular death affecting one or more parts of the lung. Necrosis is caused by diverse external and internal factors which result in the unregulated digestion of cell components. Cell blebbing (bulky morphology of the cell, disruption of cell membranes and organelles) and nucleus changes (shrunken nucleus fragments and chromatin condesation) is visible with electron microscope and DAPI staining. The release of cell contents initiates an inflammatory response in the surrounding tissue is detectable with hematoxylin and eosin staining.