Abnormal mitochondrial shape Mitochondrial hypertrophy 2021-03-07T22:44:15Z Enlargement of mitochondria. Mitochondrial hypertrophy is not discernible by light microscopy. By electron microscopy (EM), hypertrophic mitochondria have normal cristae and normal matrix density. In contrast, swollen mitochondria display swollen cristae and irregular matrix densities in EM. Megamitochondria