Gliosis Abnormal hippocampus morphology Hippocampal sclerosis 2021-04-07T12:37:41Z Hippocampal sclerosis is a neuropathologic finding characterized by neuronal loss and gliosis in the CA-1 and subiculum of the hippocampus. Mesial temporal sclerosis Hippocampal sclerosis is now recognized as one of the main causes of focal epilepsy and is present in approximately 10% of adults with new-onset focal epilepsy.