Abnormal epidermis stratum granulosum morphology Absent keratohyalin granules 2021-05-08T15:15:46Z Lack of keratohyalin granules, which are normally present in the stratum granulosum of the epidermal layer of the skin. Keratohyalin granules typically contain a mixture of keratin filament bundles, as well as the filament-associated proteins loricrin, filaggrin, and trichohyalin. These granules are insoluble in water and located within the cytoplasm where they promote dehydration of the cell. Their chief function seems to be cross-linking of keratin filaments which creates the tight barrier that is the epidermis, providing the body with an impermeable layer that protects from invasion by foreign particles. This process of cornification of the epidermis effected by KHG is known as keratinization.