Abnormal bone structure Pagetic bone lesion 2022-02-19T11:36:51Z Paget disease of bone Paget bone lesion Paget disease is a feature of several Mendelian diseases including Paget disease of bone 3 (OMIM:167250). Paget's disease of bone (PDB) is a chronic progressive metabolic bone disease characterized by abnormal activation of osteoclasts that results in abnormal bone resorption and compensatory osteogenic sclerosis. DB can affect one (monostotic form) or more (polyostotic form) regions of the skeleton, with multiple constitutive symptoms, including bone pain, bone deformity, pathological fracture, tinnitus, hearing loss, vision loss, and osteoarthritis. Osteitis deformans