Abnormal bone structure Paget disease of bone 2022-02-19T11:36:51Z A localized disorder of bone remodeling. Increased numbers of larger than normal osteoclasts initiate the process at affected skeletal sites, and the increase in bone resorption is followed by an increase in new bone formation, altering bone architecture. Paget disease is a feature of several Mendelian diseases including Paget disease of bone 3 (OMIM:167250).