Reduced tissue galactocerebrosidase activity 2022-08-17T14:32:00Z Concentration or activity of galactocerebrosidase (EC 3.2.1.46) below the lower limit of normal. This enzyme can be measured in multiple tissues including leukocytes and cultured fibroblasts. Reduced galactocerebrosidase activity is a feature of Krabbe disease. Galactosylceramidase is a lysosomal enzyme involved in the catabolism of galactosylceramide, a major lipid in myelin, kidney, and epithelial cells of the small intestine and colon Reduced circulating galactocerebrosidase activity Reduced leukocyte galactocerebrosidase activity Reduced galactocerebrosidase activity in cultured fibroblasts Abnormal tissue enzyme concentration or activity