Abnormality of circulating fibrinogen Cryofibrinogenemia 2022-11-12T12:21:29Z Cryofibrinogenemia (CF) can be detected in both healthy persons and patients with different disorders, including autoimmune diseases, cancer, infections, etc. Cryofibrinogen should be distinguished from cryoglobulin since, unlike the latter, it precipitates only in plasma and not in serum. Cryofibrinogen is an abnormal protein that forms precipitate only in plasma. consisting of fibrinogen, fibronectin, alpha1-antitrypsin and alpha2-macroglobulin.